pISSN 2005-9159
eISSN 2093-0569

Review Article

Korean J Pain 2024; 37(1): 13-25

Published online January 1, 2024 https://doi.org/10.3344/kjp.23344

Copyright © The Korean Pain Society.

Cooled radiofrequency ablation of genicular nerves for knee osteoarthritis

Myong-Hwan Karm1 , Hyun-Jung Kwon2 , Chan-Sik Kim2 , Doo-Hwan Kim2 , Jin-Woo Shin2 , Seong-Soo Choi2

1Department of Dental Anesthesiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea
2Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Correspondence to:Seong-Soo Choi
Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Tel: +82-2-3010-1538, Fax: +82-2-3010-6790, E-mail: choiss@amc.seoul.kr

Handling Editor: Francis S. Nahm

Received: December 7, 2023; Revised: December 16, 2023; Accepted: December 18, 2023

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Knee osteoarthritis (OA) is a prevalent and debilitating musculoskeletal condition that significantly affects the quality of life of millions of individuals worldwide. In recent years, cooled radiofrequency ablation (CRFA) has become a viable treatment option for knee OA. This review thoroughly evaluated the existing literature on CRFA therapy for knee OA. It delved into the mechanisms behind CRFA, evaluated its clinical efficacy, and investigated potential avenues for future research and application. The insights gained from this review are crucial for healthcare professionals, researchers, and policymakers, offering an updated perspective on CRFA's role as a viable therapeutic option for knee OA.

Keywords: Chronic Pain, Cooled Radiofrequency Ablation, Denervation, Hyaluronic Acid, Injections, Intra-Articular, Osteoarthritis, Knee, Radiofrequency Ablation, Steroids, Treatment Outcome