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pISSN 2005-9159
eISSN 2093-0569
eISSN 2093-0569
Korean J Pain 2014; 27(2): 118-124
Published online March 28, 2014 https://doi.org/10.3344/kjp.2014.27.2.118
Copyright © The Korean Pain Society.
Somayyeh Naderi1, Firouz Ghaderi Pakdel2,3*, Mostafa Ashrafi Osalou4, and Ulker Cankurt4
1Danesh Pey Hadi Co., Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
2Neurophysiology Resaerch Center, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
3Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
4Department of Histology & Embryology, School of Medicine, Dokuz EyluL University (DEU), Izmir, Turkey.
Correspondence to: Firouz Ghaderi Pakdel. Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, P.O.Box 1138 Urmia, Iran. Tel: +98-441-2240643, Fax: +98-441-2240642, info@fgpakdel.com
Received: September 24, 2013; Revised: December 24, 2013; Accepted: March 3, 2014
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The chronic pain can disturb physical, psychological, and social performances. Analgesic agents are widely used but some antidepressants (ADs) showed analgesia also. Bupropion is using for smoke cessation but it can change morphine withdrawal signs such as pain. This study tested the acute systemic effect of bupropion on formalin induced pain behavior in rats.
Wistar male healthy rats were divided into 7 groups (control, sham, and 5 treated groups with 10, 30, 90, 120, and 200 mg/kg of bupropion, i.p.). The bupropion injected 3 hours prior to formalin induced pain behavior. Formalin (50 ?l, 2.5%) was injected subcutaneously in dorsal region of right hindpaw in all animals. Nociceptive signs were observed continuously on-line and off-line each minute. Common pain scoring was used for pain assessment.
The analysis of data by one-way ANOVA showed that bupropion can reduce pain scores in the second phase but not in first phase. Bupropion decreased the licking/biting duration significantly in first and second phase of formalin test.
The results showed that bupropion has analgesic effects at systemic application. The change of second phase of the pain behavior was significant and it revealed that central mechanisms involve in bupropion analgesia.
Keywords: analgesia, antidepressant, bupropion, formalin test, pain, rat
