Fig. 3. Intrathecal injection of lentiviral interference vector targeting miR-382-5p (LV-anti-miR-382-5p) alleviated pain behavior in CCI rats. (A) The mRNA level of miR-382-5p in DRGs was detected by RT-qPCR on the day 21 of CCI surgery. (B, C) Mechanical nociceptive sensitivity and thermal nociceptive sensitivity were measured in CCI rats on days 0, 3, 7, 14 and 21 of the CCI surgery. Values are presented as mean ± standard deviation. CCI: chronic constriction injury, DRGs: dorsal root ganglions, RT-qPCR: real-time quantitative reverse transcription polymerase chain reaction, PWT: paw withdrawal threshold, PWL: paw withdrawal latency. **P < 0.01; ***P < 0.001 vs. Sham. #P < 0.05; ##P < 0.01; ###P < 0.001 vs. CCI + LV-anti-NC. n = 13.
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