Fig. 2. Elevated miR-382-5p levels in DRGs of NP rats. (A, B) Mechanical nociceptive sensitivity and thermal nociceptive sensitivity were measured in CCI rats on days 0, 3, 7, 14 and 21 of the CCI surgery. (C–E) On day 21 of CCI surgery, the levels of proinflammatory factors (IL-6, IL-1β, TNF-α) in DRGs were measured by ELISA assay. (F) The level of miR-382-5p in DRGs was measured by RT-qPCR on days 0, 3, 7, 14 and 21 of the CCI surgery. Values are presented as mean ± standard deviation. DRGs: dorsal root ganglions, NP: neuropathic pain, CCI: chronic constriction injury, IL-6: interleukin-6, IL-1β: interleukin-1β, TNF-α: tumor necrosis factor-α, PWT: paw withdrawal threshold, PWL: paw withdrawal latency. **P < 0.01; ***P < 0.001 vs. Sham. n = 4.
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