Fig. 3. Effect of salicylate and metformin (MET) co-treatment on hot plate latencies. (A) Line chart of the groups hot plate latencies thorough the days. (B) Area under curve of the line chart. Data were presented as mean ± standard error of the mean, n = 7, and analyzed by ANOVA followed by Tukey’s multiple comparison tests. (a) Compared to the control group, (b) Compared to the SS group, (c) Compared to the Met50 group, (d) Compared to the Met75 group. Met50: received MET (50 mg/kg) for 7 days, Met75: received MET (75 mg/kg) for 7 days, Met100: received MET (100 mg/kg) for 7 days, SS: received salicylate (300 mg/kg) daily for 7 days. ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05.
© Korean J Pain
