Fig. 2. Effect of different doses of metformin (MET) on hot plate latencies. (A) Line chart of hot plate latencies after MET injection at different doses over time. (B) Area under curve of the line chart. Data were presented as mean ± standard error of the mean, n = 7, and analyzed by ANOVA followed by Tukey’s multiple comparison tests. (a) Compared to the control group, (b) Compared to the Met50 group. Met50: received MET (50 mg/kg) for 7 days, Met75: received MET (75 mg/kg) for 7 days, Met100: received MET (100 mg/kg) for 7 days. ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05.
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