Effect of APE from
Treatment | Dose (mg/kg) | Latency of discomfort (sec) at respective time interval (min) | ||||||
---|---|---|---|---|---|---|---|---|
0 min | 60 min | 90 min | 120 min | 150 min | 180 min | 210 min | ||
Normal saline | - | 4.2 ± 0.4 | 4.8 ± 0.2 | 5.1 ± 0.3 | 4.3 ± 0.2 | 5.2 ± 0.3 | 5.0 ± 0.8 | 5.4 ± 0.1 |
APE | 400 | 4.0 ± 0.3 | 5.7 ± 0.6 | 7.5 ± 0.7 | 7.0 ± 1.5 | 5.3 ± 1.1 | 5.8 ± 0.8 | 6.5 ± 0.4 |
1,000 | 3.8 ± 0.6 | 5.0 ± 0.4 | 5.9 ± 0.5 | 6.5 ± 0.3 | 7.3 ± 0.9 | 7.3 ± 0.8 | 5.6 ± 0.1 | |
2,000 | 4.5 ± 0.4 | 7.6 ± 0.6 |
7.7 ± 0.8 | 9.2 ± 1.0 |
8.9 ± 0.9 |
8.5 ± 0.6 |
6.8 ± 0.6 | |
Morphine | 5 | 3.9 ± 0.2 | 9.3 ± 0.8 |
12.6 ± 1.2 |
13.1 ± 1.2 |
11.7 ± 1.3 |
10.9 ± 1.0 |
10.7 ± 0.1 |
Data indicated as mean ± standard error of the reaction time (sec) of six mice.
Mice were treated with normal saline (10 mL/kg, p.o), APE (400 mg/kg, 1,000 mg/kg, and 2,000 mg/kg, p.o), or morphine (5 mg/kg, i.p). Statistical analyses were performed using one-way ANOVA followed by Dunnett’s multiple comparisons test.
APE: aqueous propolis extract, p.o: orally, i.p: intraperitoneal.
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