Pharmacotherapy of neuropathic pain drugs
| Drug | Mechanism of action |
|---|---|
| Tricyclic antidepressants (amitriptyline) | Inhibition of noradrenaline reuptake via α2-adrenergic receptors [42] |
| Calcium channel a2δ ligand (gabapentin, pregabalin) | Acts on the a2δ subunit of the voltage-gated calcium channel [44] |
| Serotonin-noradrenaline reuptake inhibitors (duloxetine, venlafaxine) | Inhibits the reuptake of serotonin and noradrenaline [47] |
| Lamotrigine | Inhibition of voltage-gated calcium channels [46] |
| Carbamazepine | Blocks sodium channels [48] |
| Opioids (tramadol, morphine) | µ-opioid receptor agonist [49] |