rTMS study results on CPSP

Author, Year Country Study design Number of patients Stroke type rTMS site Frequency (Hz) Intensity Pulses Intertrain interval Session schedule Outcome measure
Migita et al., 1995 [97] Japan Case report 2 (1 CPSP patient) Hemorrhagic stroke M1 NA NA NA NA NA Pain relief (VAS)
Lefaucher et al., 2001 [105] France Cross-over 14 (7 CPSP patients) Infarct and hemorrhagic stroke M1 10 80% RMT 1,000 55 sec Single session Pain relief (VAS)
Khedr et al., 2005 [95] Egypt Parallel 48 (24 CPSP patients) Infarct and hemorrhagic stroke M1 20 80% RMT 2,000 NA 5 sessions Pain relief (VAS)
Saitoh et al., 2007 [98] Japan Cross-over 13 (7 CPSP patients) Infarct and hemorrhagic stroke M1 1/5/10 90% RMT 5,000 50 sec 3 sessions Pain relief in 5 Hz and 10 Hz (VAS)
Ohn et al., 2012 [68] Republic of Korea Open label trial 22 (All CPSP patients) Infarct and hemorrhagic stroke M1 10 90% RMT 1,000 55 sec 5 sessions Pain relief (VAS)
Matsumura et al., 2013 [99] Japan Cross-over 20 (All CPSP patients) Infarct and hemorrhagic stroke M1 5 100% RMT 500 25 sec Single session Pain relief (VAS)
Hosomi et al., 2013 [83] Japan Cross-over 21 (All CPSP patients) Infarct and hemorrhagic stroke M1 5 90% RMT 500 50 sec 10 sessions Pain relief (VAS)
Hasan et al., 2014 [101] United Kingdom Open label trial 14 (All CPSP patients) Infarct and hemorrhagic stroke M1 10 80%–90% MT 2,000 60 sec 5 sessions Pain relief (NRS)
de Oliveira et al., 2014 [102] Brazil Parallel 21 (All CPSP patients) Infarct and hemorrhagic stroke PMC/DLPFC 10 120% RMT 1,250 25 sec 10 sessions No effect pain relief (VAS)
Kobayashi et al., 2015 [94] Japan Open label trial 18 (All CPSP patients) Infarct and hemorrhagic stroke M1 5 90% AMT 500 50 sec 12 sessions Pain relief (VAS)
Lin et al., 2018 [91] China Open label trial 7 (All CPSP patients) Infarct and hemorrhagic stroke M1 10 90% RMT 1,000 60 sec 10 sessions Pain relief (VAS)
Zhao et al., 2021 [74] China RCT 38 (All CPSP patients) Infarct and hemorrhagic stroke M1 10 80% RMT 2,000 3 sec 18 days Pain relief (NRS)
Malfitano et al., 2021 [103] Italy Case series 1 CPSP patient Infarct stroke M1 10 90% RMT 2,000 5 sec 10 sessions Pain relief (NRS)
Ojala et al., 2022 [100] Finland RCT 17 (All CPSP patients) Infarct and hemorrhagic stroke M1/S2 10 90% MT 5,050 50 sec 10 sessions Pain relief (NRS)

rTMS: repetitive transcranial magnetic stimulation, CPSP: central post-stroke pain, RCT: randomized control trial, M1: motor cortex, S2: secondary somatosensory cortex, PMC: premotor cortex, DLPFC: dorsolateral pre-frontal cortex, RMT: resting motor threshold, MT: motor threshold, AMT: active motor threshold, NA: not available, VAS: visual analog scale, NRS: numeric rating scale.

Korean J Pain 2023;36:408~424 https://doi.org/10.3344/kjp.23220
© Korean J Pain