The certainty of evidence based on the GRADE framework
| Outcome | Number of experiments | Risk of bias | Imprecision | Inconsistency | Indirectness | Publication bias | Judgment | Level of evidence |
|---|---|---|---|---|---|---|---|---|
| Mechanical allodynia | 49 | Serious | No serious imprecision | No serious inconsistency |
No serious indirectness | No publication bias | Level of evidence was downrated one grade due to possible risk of bias | Moderate |
| Mechanical hyperalgesia | 18 | Serious | No serious imprecision | No serious inconsistency |
No serious indirectness | No publication bias | Level of evidence was downrated one grade due to possible risk of bias | Moderate |
| Thermal hyperalgesia | 13 | Serious | No serious imprecision | No serious inconsistency |
No serious indirectness | No publication bias | Level of evidence was downrated one grade due to possible risk of bias | Moderate |
GRADE: Grading of Recommendations Assessment, Development, and Evaluation.
aThere is no serious inconsistency since the sources of heterogeneity were identified.