The Korean Journal of Pain

Table 3

Subgroup analysis for the effect of muscimol on nerve injury-related neuropathic pain

Subgroups	n experiments	SMD	95% CI	P value	I² (%)	P value
Mechanical allodynia
Time of follow-up (min)
15	22	2.13	1.58, 2.68	0.000	75.02	< 0.0001
30	33	1.44	1.15, 1.73	0.000	48.63	< 0.0001
60	46	1.49	1.20, 1.78	0.000	64.47	< 0.0001
90	26	1.03	0.63, 1.42	0.000	66.79	< 0.0001
120	28	0.99	0.62, 1.36	0.000	67.05	< 0.0001
180	15	1.00	0.63, 1.37	0.000	45.44	0.024
Pain origin
Central	15	2.47	1.82, 3.11	0.000	72.59	< 0.0001
Peripheral	34	1.47	1.13, 1.82	0.000	66.05	< 0.0001
Administration site
Intrathecal	28	2.18	1.74, 2.62	0.000	68.46	< 0.0001
Intracerebral	12	1.18	0.61, 1.75	0.000	71.94	< 0.0001
Systemic	9	1.43	0.75, 2.11	0.000	67.80	0.003
Mechanical hyperalgesia
Time of follow-up (min)
15	8	2.07	1.68, 2.46	0.000	0.00	0.850
30	6	1.50	1.01, 1.99	0.000	1.23	0.389
60	14	0.87	0.57, 1.16	0.000	23.95	0.118
90	2	Lack of sufficient data
120	2	Lack of sufficient data
180	8	1.15	0.64, 1.66	0.000	49.55	0.050
Pain origin
Central	11	1.79	1.47, 2.10	0.000	0.00	0.466
Peripheral	7	1.27	0.58, 1.95	0.000	57.51	0.028
Administration site
Intrathecal	8	2.07	1.68, 2.46	0.000	0.00	0.850
Intracerebral	8	1.21	0.74, 1.67	0.000	35.25	0.142
Systemic	2	Lack of sufficient data
Thermal hyperalgesia
Time of follow-up (min)
15	6	1.87	1.43, 2.32	0.000	0.00	0.416
30	3	4.74	3.32, 6.17	0.000	39.21	0.195
60	7	–0.31	–0.66, 0.03	0.077	0.00	0.700
90	2	Lack of sufficient data
180	6	–0.13	–0.49, 0.23	0.478	0.00	0.989
Pain origin
Central	6	1.87	1.43, 2.32	0.000	0.00	0.416
Peripheral	7	3.33	1.87, 4.80	0.000	84.89	< 0.0001
Administration site
Intrathecal	6	1.87	1.43, 2.32	0.000	0.00	0.416
Intracerebral	1	Lack of sufficient data
Systemic	6	3.82	2.75, 4.90	0.000	61.01	0.029

SMD: standardized mean difference, 95% CI: 95% confidence interval.