Characteristics of the included studies

Study Animal species, sex, weight (g) Model Injury to muscimol administration (days) Dose (ng) Administration site Treatment to pain Pain type N
Treateda
N
Non-treated
Dias and Prado [39] Rat, Wistar, M, 140–160 SNL, SNL and SCI 2, 7 300 Intrathecal 15, 30, 60, 90 Mechanical allodynia 5 5
Gwak et al. [40] Rat, SD, M, 200–250 SCI 21 1,000 Intrathecal 30, 120, 180 Mechanical allodynia 5 5
Hama and Sagen [22] Rat, SD, M, 100–150 SCI 21 0.1, 0.3, 1, 3 Intrathecal 30, 60, 90, 120 Mechanical allodynia 7 7
Hosseini et al. [23] Rat, Wistar, M, 140–160 SCI 21 10, 100, 1,000 Intrathecal 15, 60, 180 Thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia 10 10
Hosseini et al. [24] Rat, Wistar, M, 140–160 SCI 24 10 Intrathecal 15, 60 Mechanical allodynia, mechanical hyperalgesia 10 10
Hwang and Yaksh [41] Rat, SD, M, 120–150 SNL 7 100, 300, 1,000 Intrathecal 15, 30, 45, 60, 120, 180 Mechanical allodynia 5-6 5-6
Jeon et al. [25] Rat, SD, N/R, 200–250 CCI 14 100, 300, 1,000, 1.71, 3.42, 1,711 Intrathecal, Intraplantar 15, 30, 45, 60, 75, 90, 105, 120 Mechanical allodynia 6 6
Jiang et al. [31] Rat, SD, M, 150–180 SNL 7 25 Intra-CeA 30 Mechanical allodynia 14 14
LaGraize and Fuchs [42] Rat, SD, M, 3–4 mo SNL 3 1, 100, 500 Intra rostral anterior cingulate cortex 35 Mechanical allodynia 8 10
Lee et al. [26] Rat, SD, M, 150–200 Caudal trunk nerve cut 14 1,000 Intrathecal 30 Mechanical allodynia 7 5
Lee et al. [27] Rat, SD, M, 180–200 CCI 7 570 Intrathecal 30, 60, 90, 120, 180 Mechanical allodynia 8 10
Moon et al. [28] Rat, SD, M, 250–300 SCI 14 570, 1,140, 1,700 ZI 60 Mechanical hyperalgesia 10 10
Moon and Park [29] Rat, SD, M, 250–300 CCI 10 285, 2,830 ZI 120 Mechanical allodynia 10 10
Nasirinezhad et al. [43] Rat, Wistar, M, 140–160 SCI 24 10, 100, 1,000 Intrathecal 15, 60, 180 Mechanical hyperalgesia, thermal hyperalgesia, mechanical allodynia 8 8
Pedersen et al. [30] Rat, SD, M, 180–200 CCI 14 20, 50 CeA 30 Mechanical allodynia, mechanical hyperalgesia 8 6
Rashid and Ueda [32] Mice, ddY, M, 25–30 CCI 0 3.42, 11.4, 34.2 Intrathecal 60 Mechanical allodynia 6 6
Rode et al. [33] Rat, SD, M, 250 SNI 0 Sub-cutaneous 30, 60, 90, 120, 150 Mechanical allodynia, mechanical hyperalgesia 6 6
Sadeghi et al. [34] Rat, Wistar, M, 200–250 CCI 14 112,500, 225,000, 450,000 Intra-peritoneal 30 Thermal hyperalgesia, mechanical allodynia 8 8
Seno et al. [35] Rat, Wistar, M, 180–200 CCI 14 500 CeA, BLA 30 Mechanical hyperalgesia, mechanical allodynia 8 5
Wei et al. [36] Rat, Hannover-Wistar, M, 180–250 CCI 4 100, 300 Hypothalamus A11 15, 30, 60 Mechanical allodynia, mechanical hyperalgesia, thermal hyperalgesia 5-6 6
Yowtak et al. [37] Mice, GAD67-EGFP, M, N/R CCI 4 50, 100 Intrathecal 30, 60, 90, 120 Mechanical allodynia 8 8
Zarrindast and Mahmoudi [38] Mice, albino NMRI, M, 20–25 SNI 14 10,000, 20,000, 40,000 Intra-peritoneal 75 Thermal hyperalgesia 8 8

SNL: sciatic nerve ligation, SCI: spinal cord injury, CCI: chronic compression injury, SNI: sciatic nerve injury, CeA: central nuclei of the amygdala, ZI: zona incerta, BLA: basolateral nuclei of the amygdala, N/R: not recorded.

aThe number of animals was reported as number of animals per each treated group. Some studies had several experimental groups according to dose of muscimol, site of administration and model of pain induction.

Korean J Pain 2023;36:425~440 https://doi.org/10.3344/kjp.23161
© Korean J Pain