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Fig. 6. The antisense oligodeoxynucleotides against DRP1 suppressed NR2B expression in remifentanil-induced hyperalgesia. Representative fluorescence immunohistochemistry images for NR2B levels in groups A–D: (A) Group control, (B) Group remifentanil, (C) Group MM, (D) Group AS. The selected field was analyzed by a confocal microscope (magnification: ×400). (E) Statistical assessment of positive cells post fluorescence immunostaining in the spinal dorsal horn. DAPI was used to stain the nuclei (mean ± standard deviation, n = 3). The arrows represented NR2B positive neurons. Scale bars = 25 μm. C: group control, R: group remifentanil, MM: group mismatch oligodeoxynucleotides to dynamin-related protein 1, AS: group antisense oligodeoxynucleotides against dynamin-related protein 1. **P < 0.01 compared with the group control, #P < 0.05 compared with the group AS.
Korean J Pain 2023;36:316~327
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