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Fig. 4. (A, B) The effect of the AS on hyperalgesia induced by remifentanil. PWTL (A) and PWMT (B) were measured in rats at 24 hour before (baseline) and at 4, 8, 24, and 48 hour post-remifentanil infusion (mean ± standard deviation, n = 15). C: group control, R: group remifentanil, MM: group mismatch oligodeoxynucleotides to dynamin-related protein 1, AS: group antisense oligodeoxynucleotides against dynamin-related protein 1, PWTL: paw withdrawal thermal latency, PWMT: paw withdrawal mechanical threshold. ***P < 0.001 compared with the group control. ###P < 0.001 compared with the group AS.
Korean J Pain 2023;36:316~327
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