Fig. 5. Antinociceptive effect of microinjection of 4, 8 or 12 µg of AIP into NAc in rats showing morphine tolerance. The left HWL are depicted in A (noxious thermal stimulation) and C (noxious mechanical stimulation); the right HWL are shown in B (noxious thermal stimulation) and D (noxious mechanical stimulation). 4, 8 or 12 µg of AIP was injected into NAc 10 minutes prior to intraperitoneal injection of 10 mg/kg morphine. Time = 0 min, indicates the start of intraperitoneal morphine injection. The data of the experiment are expressed as mean ± standard error of the mean. Two-way ANOVA was employed to analyze statistical differences among groups. ***P < 0.001 means relative to the control group. AIP: autocamtide-2-related inhibitory peptide, HWL: hindpaw withdrawal latency, NAc: nucleus accumbens.
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