Fig. 4. Changes in CaMK II expression in morphine-tolerant rat NAc. (A) p-CaMK II/t-CaMK II and GAPDH western blotting results of the saline control and morphine tolerance groups. (B) p-CaMK II/t-CaMK II ratios are shown in histograms. The data of the experiment are expressed as mean ± standard error of the mean. Two-tailed Student’s t-test was employed to analyze statistical differences among groups. Differences with **P < 0.01 are deemed statistically significant. CaMK II: calcium/calmodulin-dependent protein kinase, NAc: nucleus accumbens, p-CaMK II: phosphorylated CaMK II, t-CaMK II: total CaMK II, GAPDH: glyceraldehyde-3-phosphate dehydrogenase.
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