Fig. 1. Antinociceptive effect of microinjection of 4, 8 or 12 µg of AIP into NAc in naïve rats. The left HWL are shown in A (noxious thermal stimulation) and C (noxious mechanical stimulation); the right HWLs are depicted in B (noxious thermal stimulation) and D (noxious mechanical stimulation). The data in the experiment are expressed as mean ± standard error of the mean. Two-way ANOVA was employed to analyze the statistical difference among experimental groups. ***P < 0.001 means relative to the control group. AIP: autocamtide-2-related inhibitory peptide, NAc: nucleus accumbens, HWL: hindpaw withdrawal latency.
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