Fig. 4. The antinociceptive effect of triazine derivatives in hot plate test. Vehicle (10 mL/kg), test compounds (200 mg/kg) and morphine (10 mg/kg) were injected intraperitoneally to mice and the latency time was recorded at 0, 30, 60, 90, and 120 minutes. The percent of maximum possible antinociceptive effect (MPE%) was calculated for each time interval and compared. Data shows mean ± SEM of 6 animals in each group. 5c: 4-(4-(4-formyl-3-methoxyphenoxy)−6–chloro-1,3,5-triazin-2-ylamino)benzonitrile, 5d: 4-(4-(p-tolylamino)−6–chloro-1,3,5-triazin-2-yloxy)−2-methoxybenzaldehyde, 10a: 4–chloro-N-methyl-6-(4-phenyl-1H-pyrazol-1-yl)−1,3,5-triazin-2-amine, 10b: 4–chloro-N-ethyl-6-(4-phenyl-1H-pyrazol-1-yl)−1,3,5-triazin-2-amine, 10e: 2,4-dichloro-6-(4-phenyl-1H-pyrazol-1-yl)−1,3,5-triazine, SEM: standard error of the mean. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to control group.
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