Fig. 3. Antinociceptive effect of different doses of compounds 10a, 10b, and 10e in formalin test. Control animals received vehicle (10 mL/kg, i.p.). Compounds 10a, 10b, and 10e (50, 100, and 200 mg/kg) and morphine (10 mg/kg) were injected intraperitoneally. Thirty minutes later formalin (20 microliters, 2.5% v/v) was injected into the right hind paw of the animals. The time spent for paw licking was considered as an index of pain severity. Data shows mean ± SEM of 6 animals in each group. 10a: 4–chloro-N-methyl-6-(4-phenyl-1H-pyrazol-1-yl)−1,3,5-triazin-2-amine, 10b: 4–chloro-N-ethyl-6-(4-phenyl-1H-pyrazol-1-yl)−1,3,5-triazin-2-amine, 10e: 2,4-dichloro-6-(4-phenyl-1H-pyrazol-1-yl)−1,3,5-triazine, i.p.: intraperitoneal, SEM: standard error of the mean. **P < 0.01, ***P < 0.001 compared to control group.
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