Fig. 2. Antinociceptive effect of three different doses of compound 5c and 5d in formalin test. Control animals received vehicle (10 mL/kg, i.p.). Compound 5c and 5d (50, 100, and 200 mg/kg) and morphine (10 mg/kg) were injected intraperitoneally. Thirty minutes later formalin (20 microliters, 2.5% v/v) was injected into the right hind paw of the animals. The time spent for paw licking was considered as an index of pain severity. Data shows mean ± SEM of 6 animals in each group. 5c: 4-(4-(4-formyl-3-methoxyphenoxy)−6–chloro-1,3,5-triazin-2-ylamino)benzonitrile, 5d: 4-(4-(p-tolylamino)−6–chloro-1,3,5-triazin-2-yloxy)−2-methoxybenzaldehyde, i.p.: intraperitoneal, SEM: standard error of the mean. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to control group.
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