Antinociceptive effect of triazine derivatives in acetic acid-induced writhing test in mice
| Compound | Dose (mg/kg) | Number of writhings | Percent inhibition |
|---|---|---|---|
| Control | – | 69.9 ± 3.5 | – |
| 5c | 50 | 27.8 ± 3.1 |
60% |
| 100 | 19.7 ± 7.6 |
71% | |
| 200 | 15.5 ± 6.6 |
77% | |
| 5d | 50 | 18.5 ± 6.2 |
73% |
| 100 | 6.4 ± 5.5 |
90% | |
| 200 | 6.0 ± 3.9 |
91% | |
| 10a | 50 | 7.7 ± 3.5 |
88% |
| 100 | 7.5 ± 4.4 |
89% | |
| 200 | 2.8 ± 1.0 |
95% | |
| 10b | 50 | 16.8 ± 3.9 |
75% |
| 100 | 13.4 ± 3.9 |
80% | |
| 200 | 1.0 ± 0.8 |
98% | |
| 10e | 50 | 31.7 ± 3.0 |
54% |
| 100 | 7.5 ± 0.4 |
89% | |
| 200 | 4.7 ± 2.2 |
93% | |
| Indomethacin | 10 | 3.3 ± 1.3 |
95% |
Data shows mean ± SEM of six mice in each group.
5c: 4-(4-(4-formyl-3-methoxyphenoxy)−6–chloro-1,3,5-triazin-2-ylamino)benzonitrile, 5d: 4-(4-(p-tolylamino)−6–chloro-1,3,5-triazin-2-yloxy)−2-methoxybenzaldehyde, 10a: 4–chloro-N-methyl-6-(4-phenyl-1H-pyrazol-1-yl)−1,3,5-triazin-2-amine, 10b: 4–chloro-N-ethyl-6-(4-phenyl-1H-pyrazol-1-yl)−1,3,5-triazin-2-amine, 10e: 2,4-dichloro-6-(4-phenyl-1H-pyrazol-1-yl)−1,3,5-triazine, SEM: standard error of the mean.
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