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Fig. 3. The effects of normal saline (NS) and L-arginine (L-Arg) infusion into medial prefrontal cortex (mPFC) on spared nerve injury (SNI) induced mechanical allodynia. Values represent the mean ± SEM (n = 6 animals per group). A three-minute time interval before recordings of mechanical allodynia was used to microinject saline and L-Arg. (A) The paw withdrawal threshold fifty percent (50% PWT) change before and after drugs infusion. Different letters represent significant differences (P < 0.001, two way ANOVA and Bonferroni post hoc tests) for all time-points after microinjections of L-Arg at doses of 2.87, 11.5, and 45.92 nmol compared with NS group in SNI rats. (B) Related area under the curve (AUC) of mechanical allodynia after microinjection of NS and L-Arg. Different letters represent significant differences (P < 0.001) using one way ANOVA and Tukey’s post hoc tests. (C) Dose-response curve of L-Arg on SNI-induced allodynia. LA: L-Arg, SEM: standard error of the mean, ANOVA: analysis of variance.
Korean J Pain 2022;35:413~422
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