Fig. 3. In chronic constriction injury (CCI) rats, the paw withdrawal thresholds (PWTs) and paw withdrawal latencies (PWLs) in the ipsilateral side were decreased from day 3 after modeling. Botulinum toxin type A (BTX-A) (4, 7, 10 U/kg) reversed these decreases from day 10 in a dose-dependent manner (A, C). The PWTs and PWLs of the contralateral side in each group exhibited no significant changes in time points (B, D). The error bar means mean ± standard deviation. aP < 0.05 vs. CCI + normal saline (NS) group, Two-way ANOVA, n = 6 in each group; bP < 0.05 vs. CCI + 4 U/kg BTX-A group, Two-way ANOVA, n = 6 in each group; cP < 0.05 vs. CCI + 7 U/kg BTX-A group, Two-way ANOVA, n = 6 in each group.
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