Evaluation NTG-induced spontaneous migraine-like headache symptoms between groups
| Group | Spontaneous orofacial pain behavior | ||
|---|---|---|---|
| Head shaking | Ipsilateral hind paw facial grooming | Freezing | |
| Intact | 230.83 ± 32.84 | 10.00 ± 5.16 | 768.33 ± 39.61 |
| NTG | 467.50 ± 53.45 |
39.16 ± 12.93 | 1,958.33 ± 204.53 |
| NTG + DMSO | 379.16 ± 24.67 | 42.50 ± 8.73 | 1,729.00 ± 107.87 |
| NTG + SB (10 nM) | 467.50 ± 49.87 |
92.50 ± 9.81 |
4,240.00 ± 65.01 |
| NTG + SB (20 nM) | 594.16 ± 49.60 |
93.33 ± 10.46 |
3,778.33 ± 96.89 |
| NTG + SB (40 nM) | 770.83 ± 31.07 |
110.00 ± 20.08 |
4,270.83 ± 140.66 |
Values are presented as mean ± standard error of the mean (n = 6).
NTG: nitroglycerin, DMSO: dimethylsulfoxide, SB: SB-334867.
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