Table. 1.

Evaluation NTG-induced spontaneous migraine-like headache symptoms between groups

Group Spontaneous orofacial pain behavior
Head shaking Ipsilateral hind paw facial grooming Freezing
Intact 230.83 ± 32.84 10.00 ± 5.16 768.33 ± 39.61
NTG 467.50 ± 53.45** 39.16 ± 12.93 1,958.33 ± 204.53***
NTG + DMSO 379.16 ± 24.67 42.50 ± 8.73 1,729.00 ± 107.87***
NTG + SB (10 nM) 467.50 ± 49.87** 92.50 ± 9.81*** 4,240.00 ± 65.01***,###
NTG + SB (20 nM) 594.16 ± 49.60** 93.33 ± 10.46***,# 3,778.33 ± 96.89***,###
NTG + SB (40 nM) 770.83 ± 31.07***,## 110.00 ± 20.08***,## 4,270.83 ± 140.66***,###

Values are presented as mean ± standard error of the mean (n = 6).

NTG: nitroglycerin, DMSO: dimethylsulfoxide, SB: SB-334867.

**P < 0.01, ***P < 0.001 vs. control group, #P < 0.05, ##P < 0.01, ###P < 0.001 vs. NTG group.

Korean J Pain 2022;35:22~32 https://doi.org/10.3344/kjp.2022.35.1.22
© Korean J Pain