Fig. 3. Naloxone challenge test on the 14th and 21st day. The paw withdrawal threshold (PWT) after spinal nerve ligation (SNL) did not change after the intraperitoneal administration of naloxone (2 mg/kg) either at 30 or 60 minutes. No signs of opioid withdrawal were observed until 60 minutes. Group SOG192-N: administered Sec-O-glucosylhamaudol at 192 μg/day for 2 weeks using an osmotic pump after the 7th day following SNL and subjected to the naloxone challenge test.
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