Fig. 2. Paw withdrawal threshold (PWT) during observational periods. The PWT was observed on the 7th, 14th, and 21st day after spinal nerve ligation (SNL). On the 7th day after SNL, mechanical allodynia was confirmed in all rats based on a significant decrease in PWT compared to that in group S (P < 0.001). There were no significant differences among experimental groups including groups D, SOG96, and SOG192. The rats treated with continuous administration of Sec-O-glucosylhamaudol (SOG) intrathecally (group SOG96 and group SOG192) showed a higher PWT than those in the control group (group D) on the 14th and 21st day after SNL (P < 0.001). There were no significant differences in the PWT between groups SOG96 and SOG192 during the observational periods (P = 0.728 on 7th day; P = 0.089 on 21st day). Group S: sham-operated, Group D: control group treated with 70% dimethylsulfoxide after 7th day following SNL, Group SOG96: administered SOG at 96 μg/day for 2 weeks using an osmotic pump after the 7th day following SNL, Group SOG192: administered SOG at 192 μg/day for 2 weeks using an osmotic pump after the 7th day following SNL. *P < 0.05 compared with group D.
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