Adverse effects during treatment
| Symptom | Control group (n = 97) | Hydromorphone group (n = 96) | |||||
|---|---|---|---|---|---|---|---|
| 1 week | 4 weeks | 12 weeks | 1 week | 4 weeks | 12 weeks | ||
| Nausea | 0 (0) | 0 (0) | 0 (0) | 5 (5.2) | 0 (0) | 0 (0) | |
| Vomiting | 0 (0) | 0 (0) | 0 (0) | 1 (1.0) | 0 (0) | 0 (0) | |
| Pruritus | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
| Constipation | 0 (0) | 0 (0) | 0 (0) | 2 (2.1) | 0 (0) | 0 (0) | |
| Difficulty passing urine | 0 (0) | 0 (0) | 0 (0) | 2 (2.1) | 0 (0) | 0 (0) | |
| Drowsiness | 3 (3.1) | 2 (2.1) | 3 (3.1) | 2 (2.1) | 1 (1.0) | 1 (1.0) | |
| Dizziness | 5 (5.2) | 4 (4.1) | 3 (3.1) | 5 (5.2) | 2 (2.1) | 0 (0) | |
| Respiratory depression | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
| Sweating | 0 (0) | 0 (0) | 0 (0) | 3 (3.1) | 0 (0) | 0 (0) | |
| Total | 8 (8.2) | 6 (6.2) | 6 (6.2) | 20 (20.8) | 3 (3.1) | 1 (1.0) | |
Values are presented as number (%).