Fig. 4. Effects of cytokine receptor blockade on the expression of phosphorylated phosphoinositide 3-kinase (p-PI3K) and phosphorylated mammalian target of rapamycin (p-mTOR). (A-C) Infusion of the respective receptor inhibitors (interleukin [IL]-1Ra, SC144, and etanercept [ETAN]) into the periaqueductal gray resulted in decreased levels of p-PI3K and p-mTOR in streptozotocin (STZ) rats (n = 8). Interestingly, no differences were found between control animals and STZ rats administered these inhibitors (n = 12). The error bars indicate standard error. aP < 0.05 vs. control rats (n = 8).
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