VZV DNA- and Anti-VZV Antibody-based Detection of VZV Reactivation in ZSH

Detection situation VZV DNA Anti-VZV antibody

Anti-VZV IgG Anti-VZV IgM
Sample CSF, serum, saliva CSF, serum CSF, serum
Detection method Polymerase chain reaction ELISA ELISA
Advantage High sensitivity Convenient kit Convenient kit, reflect early reactivation
Disadvantage Could be false negative results for latent VZV reactivation Could be false negative results for early VZV reactivation Early antibodies, narrow time window for early VZV reactivation detection

VZV: varicella-zoster virus, ZSH: zoster sine herpete, IgG: immunoglobulin G, IgM: immunoglobulin M, CSF: cerebrospinal fluid, ELISA: enzyme linked immunosorbent assay.

Korean J Pain 2020;33:208~215 https://doi.org/10.3344/kjp.2020.33.3.208
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