Table. 6.

Antidepressants Commonly Used to Treat Pain

Antidepressant Analgesia Reuptake inhibition Adverse effects Elimination of half-life of parent drug (hr)


NE SE Anticholinergic effects Postural hypotension Sedation Cardiac arrhythmia
Nortriptyline +++ ++ ++ ++ + + +++ 18-48
Amitriptyline +++ ++ ++ +++ +++ +++ +++ 9-46
Imipramine +++ ++ ++ +++ +++ ++ +++ 6-28
Desipramine ++ +++ 0 + ++ + +++ 12-28
Paroxetine + 0 +++ 0 0 0 0 21
Citalopram + 0 +++ 0 0 0 0 24
Venlafaxine ? ++ +++ 0 0 0 0 4

NE: norepinephrine, SE: serotonin.

Modified from Max and Gilron (Antidepressants, muscle relaxants, and N-methyl-D-aspartate receptor antagonists. In: Bonica’s Management of Pain. 3rd ed. Edited by Loeser JD; 2000, pp. 1710-26) [59].

Korean J Pain 2020;33:108~120 https://doi.org/10.3344/kjp.2020.33.2.108
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