Table. 5.

Different Titration Methods and Conversion of Gabapentin and Pregabalin for Patients with Intractable Pain Requiring a Rapid Dose Increase

Day Gabapentin Pregabalin


TID Total daily dose QID BID Total daily dose TID




7A 1P 7P 7A 1P 7P 11P 7A 7P 7A 3P 11P
1 - - 300 300 - - - 300 50 50 100 25 25 50
2 300 - 300 600 100 100 100 300 75 75 150 50 50 50
3 300 300 300 900 200 200 200 300 100 100 200 50 50 100
4-6 400 400 400 1,200 300 300 300 300 150 150 300 75 75 150
7-10 500 500 500 1,500 300 300 300 600 200 200 400 100 100 200
11-14 600 600 600 1,800 400 400 400 600 250 250 500 125 125 250
15 800 800 800 2,400 600 600 600 600 300 300 600 150 150 300

TID: ter in die; three times a day, QID: quarter in die; four times in a day, BID: bis in die; twice in a day, -: not available.

Modified from the article of Yang et al. (Korean J Anesthesiol 2013; 65: 48-54) [52].

Korean J Pain 2020;33:108~120 https://doi.org/10.3344/kjp.2020.33.2.108
© Korean J Pain