Cited by CrossRef (70)

  1. Mohamed Amin Ghobadifar, Navid Kalani. The Potential Role of Intrathecal Nefopam in the Management of Neuropathic Pain. Korean J Pain 2014;27:301
    https://doi.org/10.3344/kjp.2014.27.3.301
  2. Samina Khatib, Syed S.N. Razvi, Mudassir M. Shaikh, Mohammad Moizuddin Khan. Updates in Anesthesia - The Operating Room and Beyond. 2014.
    https://doi.org/10.5772/intechopen.109093
  3. Alexandre da Silva, Sinda Lepetre-Mouelhi, Patrick Couvreur. Micro- and nanocarriers for pain alleviation. Advanced Drug Delivery Reviews 2022;187:114359
    https://doi.org/10.1016/j.addr.2022.114359
  4. Isra Omar, Husna Mirza, Sebastien Taurin. Theory and Applications of Nonparenteral Nanomedicines. 2022.
    https://doi.org/10.1016/B978-0-12-820466-5.00018-1
  5. Young Min Ok, Ji Hyun Cheon, Eun Ji Choi, Eun Jung Chang, Ho Myung Lee, Kyung Hoon Kim. Nefopam Reduces Dysesthesia after Percutaneous Endoscopic Lumbar Discectomy. Korean J Pain 2016;29:40
    https://doi.org/10.3344/kjp.2016.29.1.40
  6. Eunhye Choi, Myong-Hwan Karm, Eunsun So, Yoon Ji Choi, Sookyung Park, Yul Oh, Hye Joo Yun, Hyun Jeong Kim, Kwang-Suk Seo. Effects on postoperative nausea and vomiting of nefopam versus fentanyl following bimaxillary orthognathic surgery: a prospective double-blind randomized controlled trial. J Dent Anesth Pain Med 2019;19:55
    https://doi.org/10.17245/jdapm.2019.19.1.55
  7. Hyun Jung Koh, Jin Joo, Yang-Soo Kim, Yu Jung Lee, Woojoo Yoo, Min Soo Lee, Hue Jung Park. Analgesic Effect of Low Dose Nefopam Hydrochloride after Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial. JCM 2019;8:553
    https://doi.org/10.3390/jcm8040553
  8. Ki Tae Jung, Keum Young So, Seung Chul Kim, Sang Hun Kim. Effect of Nefopam-Based Patient-Controlled Analgesia with and without Fentanyl on Postoperative Pain Intensity in Patients Following Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Non-Inferiority Trial. Medicina 2021;57:316
    https://doi.org/10.3390/medicina57040316
  9. Harmantya Mahadhipta, Ajiantoro, Reza Abidin Shihab, Riky Febriansyah Saleh, Jephtah Furano Lumban Tobing, Luthfi Gatam, Syafruddin Husin, Phedy, Asrafi Rizki Gatam. A case report of percutaneous endoscopic debridement for treating lumbar tuberculous spondylitis with large psoas abscess. International Journal of Surgery Case Reports 2022;93:106850
    https://doi.org/10.1016/j.ijscr.2022.106850
  10. Georg A. Petroianu, Lujain Aloum, Abdu Adem. Neuropathic pain: Mechanisms and therapeutic strategies. Front. Cell Dev. Biol. 2023;11
    https://doi.org/10.3389/fcell.2023.1072629
  11. Sejong Jin, Yoon Sook Lee, Dahyeon Kim, Bum-Joon Kim, Jae Hwan Kim, Eun-Su Choi. Effect of Nefopam on Dysesthesia, Postoperative Pain, and Satisfaction in Patients with Lumbar Spinal Stenosis Undergoing Spine Surgery: A Double-Blind, Randomized Study. JCM 2023;12:7468
    https://doi.org/10.3390/jcm12237468
  12. Piya Pinsornsak, Sorachat Sukkarnkosol, Krit Boontanapibul. Does Nefopam Provide Analgesic Effect and Reduce Morphine Consumption After Primary Total Knee Arthroplasty? A Prospective, Double-Blind, Randomized Controlled Trial. The Journal of Arthroplasty 2022;37:845
    https://doi.org/10.1016/j.arth.2022.01.079
  13. Manee Raksakietisak, Pranee Rushatamukayanunt, Kulanong Wilaiwan, Chakkarin Homprasert, Akkapong Nitising, Prasert Sawasdiwipachai, Chanitda Pantubtim. Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial. 2022;101:e31296
    https://doi.org/10.1097/MD.0000000000031296
  14. Gabriel O. Anyanwu, Dorathy O. Anzaku. Phytochemical Drug Discovery for Central Nervous System Disorders. 2022.
    https://doi.org/10.1002/9781119794127.ch7
  15. Mark Banting. Enteral nefopam for pain control at the end of life. BMJ Support Palliat Care 2023;13:181
    https://doi.org/10.1136/spcare-2023-004249
  16. Ajit Rai, Howard Meng, Aliza Weinrib, Marina Englesakis, Dinesh Kumbhare, Liza Grosman-Rimon, Joel Katz, Hance Clarke. A Review of Adjunctive CNS Medications Used for the Treatment of Post-Surgical Pain. CNS Drugs 2017;31:605
    https://doi.org/10.1007/s40263-017-0440-1
  17. Jun-Ho Hong, Su-Jin Kim, Min-Sub Hwang. Comparison of effect of electroacupuncture and nefopam for prevention of postanesthetic shivering in patients undergoing urologic operation under spinal anesthesia. Korean J Anesthesiol 2016;69:579
    https://doi.org/10.4097/kjae.2016.69.6.579
  18. Do Yun Kim, Joo Wung Chae, Chang Hun Lim, Bong Ha Heo, Keun Suk Park, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Woong Mo Kim. The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain. Korean J Pain 2016;29:164
    https://doi.org/10.3344/kjp.2016.29.3.164
  19. Ki Tae Jung, Sang Hun Kim, Keum Young So, Hyun Mae Moon. Combination of nefopam and remifentanil is more effective to reduce rocuronium-induced withdrawal response compared with remifentanil alone: a prospective, double-blinded, randomized control study. Anesth Pain Med 2018;13:53
    https://doi.org/10.17085/apm.2018.13.1.53
  20. Fa-ngam Charoenpol, Nutchanok Khampitak, Charinee Aimnang, Kachit Pachirat, Wichien Sirithanaphol, Ukrit Rompsaithong, Pakorn Kiatsopit, Supanut Lumbiganon. Single-dose intravenous nefopam on postoperative catheter-related bladder discomfort in patients undergoing transurethral resection of prostate: a randomized, double-blind placebo-controlled trial. J Anesth 2023;37:72
    https://doi.org/10.1007/s00540-022-03130-y
  21. Jingwen Ren, Ting Yu, Ye Tian, Guangheng Luo. Comparative effectiveness of interventions for managing urological postoperative catheter-related bladder discomfort: a systematic review and network meta-analysis. BMC Urol 2023;23
    https://doi.org/10.1186/s12894-023-01195-9
  22. Yong Woo Cheon, Seon Hwan Kim, Jin Hyub Paek, Jin A Kim, Yong Kyung Lee, Jin Hye Min, Hyung Rae Cho. Effects of nefopam on catheter-related bladder discomfort in patients undergoing ureteroscopic litholapaxy. Korean J Anesthesiol 2018;71:201
    https://doi.org/10.4097/kja.d.18.27113
  23. Yogesh Kumar Swarnkar, Rajiv Gupta, Anand Mohan Arora, Tuhin Mistry. Comparison of Intravenous Nefopam and Tramadol for Postoperative Analgesia in Adult Patients Scheduled for Laparoscopic Abdominal Surgeries under General Anesthesia. 2022;23:25
    https://doi.org/10.4103/TheIAForum.TheIAForum_156_21
  24. Qian Li, Quankun Zhuang, Yaru Gu, Cailing Dai, Xiaoxiao Gao, Xiaomin Wang, Huimin Wen, Xin Li, Yuyang Zhang. Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents. biom rep 2017
    https://doi.org/10.3892/br.2017.1032
  25. Joo Wung Chae, Dong Ho Kang, Yaqun Li, Seung Hoon Kim, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Woong Mo Kim. Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord. Neuroscience Letters 2020;731:135057
    https://doi.org/10.1016/j.neulet.2020.135057
  26. Kyung-Hoon Kim, Hyo-Jung Seo, Salahadin Abdi, Billy Huh. All about pain pharmacology: what pain physicians should know. Korean J Pain 2020;33:108
    https://doi.org/10.3344/kjp.2020.33.2.108
  27. AbhijitS Nair. Nefopam: Another Pragmatic Analgesic in Managing Chronic Neuropathic Pain. Indian J Palliat Care 2019;25:482
    https://doi.org/10.4103/IJPC.IJPC_215_18
  28. Jee Youn Moon, Sang Sik Choi, Shin Young Lee, Mi Kyung Lee, Jung Eun Kim, Ji Eun Lee, So Hyun Lee. The Effect of Nefopam on Postoperative Fentanyl Consumption: A Randomized, Double-blind Study. Korean J Pain 2016;29:110
    https://doi.org/10.3344/kjp.2016.29.2.110
  29. Pornpan Chalermkitpanit, Wicharn Yingsakmongkol, Worawat Limthongkul, Teerachat Tanasansomboon, Patt Pannangpetch, Nattapat Tangchitcharoen, Weerasak Singhatanadgige. Perioperative Intravenous Nefopam on Pain Management and Ambulation after Open Spine Surgery: A Randomized Double-Blind Controlled Study. Asian Spine J 2023;17:632
    https://doi.org/10.31616/asj.2022.0358
  30. Seon-Hee Oh, Myung Ha Yoon, Kyung Joon Lim, Byung Sik Yu, In Gook Jee, Ki Tae Jung. Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation. BMC Anesthesiol 2018;18
    https://doi.org/10.1186/s12871-018-0559-8
  31. Marvin Thepsoparn, Nattha Prasitthipayong, Patt Pannangpetch. Intravenous lidocaine bolus for reducing nefopam-induced venous pain: A randomized, intrasubject comparison trial. 2023;39:245
    https://doi.org/10.4103/joacp.joacp_224_21
  32. Pornpan Chalermkitpanit, Worawat Limthongkul, Wicharn Yingsakmongkol, Marvin Thepsoparn, Patt Pannangpetch, Nattapat Tangchitcharoen, Teerachat Tanasansomboon, Weerasak Singhatanadgige. Analgesic Effect of Intravenous Nefopam for Postoperative Pain in Minimally Invasive Spine Surgery: A Randomized Prospective Study. Asian Spine J 2022;16:651
    https://doi.org/10.31616/asj.2021.0337
  33. Hoda Mohamed Bayoumi, Doaa Hamed Abdelaziz, Nouran Omar El Said, Sherif Boraii, Ehab Rasmy Bendas. Postoperative pain management following laparoscopic cholecystectomy-non-opioid approaches: a review. Futur J Pharm Sci 2024;10
    https://doi.org/10.1186/s43094-024-00697-z
  34. Gianna Dipalma, Angelo Michele Inchingolo, Giulia Latini, Laura Ferrante, Paola Nardelli, Giuseppina Malcangi, Irma Trilli, Francesco Inchingolo, Andrea Palermo, Alessio Danilo Inchingolo. The Effectiveness of Curcumin in Treating Oral Mucositis Related to Radiation and Chemotherapy: A Systematic Review. Antioxidants 2024;13:1160
    https://doi.org/10.3390/antiox13101160
  35. So Yeon Lee, Dong Hyun Kim, Jung Hyun Park, Min Suk Chae. Impact of Intraoperative Nefopam on Postoperative Pain, Opioid Use, and Recovery Quality with Parietal Pain Block in Single-Port Robotic Cholecystectomy: A Prospective Randomized Controlled Trial. Medicina 2024;60:848
    https://doi.org/10.3390/medicina60060848
  36. Seok-Jin Lee, Tae-Yun Sung. Emergence agitation: current knowledge and unresolved questions. Korean J Anesthesiol 2020;73:471
    https://doi.org/10.4097/kja.20097
  37. Ahmed N Al-Nasrawi, Mustafa W Al-Ibrahim , Saifali S Aljabran . Evaluating the Efficacy of Methocarbamol and Nefopam in Orthopedic Surgical Pain. 2024
    https://doi.org/10.7759/cureus.59533
  38. Woratanat Kachacheewa, Thitima Wattanavijitkul, Siwadol Wongsak, Theerawat Chalacheewa. Morphine-Sparing Effect of Intermittent Versus Continuous Intravenous Infusion of Nefopam in Patients After Total Knee Arthroplasty: A Randomized Trial. Rama Med J 2024;47:12
    https://doi.org/10.33165/rmj.2024.47.3.268540
  39. Abdelmalek Ghimouz. Le traitement antalgique des douleurs cancéreuses. La Revue de l'Infirmière 2015;64:16
    https://doi.org/10.1016/j.revinf.2015.01.005
  40. YoonJu Go, Jun-Young Chung, Jae-woo Yi, Bong-Jae Lee, Hyungseok Seo. The effect of using nefopam in fentanyl-based intravenous patient-controlled analgesia on the incidence of postoperative nausea and vomiting in laparoscopic gynecological surgery. Med Biol Sci Eng 2021;4:20
    https://doi.org/10.30579/mbse.2021.4.1.20
  41. Deepali Valecha, K K Arora, Swapnil Kumar Barasker. A double blinded randomized prospective trial of comparison between control and study group, nefopam versus tramadol on shivering scores after spinal anesthesia in patients undergoing Transurethral resection of prostate. Perioperative Care and Operating Room Management 2024;37:100433
    https://doi.org/10.1016/j.pcorm.2024.100433
  42. Konstantinos Alfaras-Melainis, Rohesh J. Fernando, Michael L. Boisen, Paul J. Hoffman, Daniel J. Rosenkrans, Emily Teeter, Alessandra I. Cardi, Jeremy Laney, Aaron Reagan, Vidya K. Rao, Michael Anderson, Charles B. Luke, Sudhakar Subramani, Travis Schisler, Peter J. Ritchie, Theresa A. Gelzinis. The Year in Thoracic Anesthesia: Selected Highlights from 2022. Journal of Cardiothoracic and Vascular Anesthesia 2024;38:29
    https://doi.org/10.1053/j.jvca.2023.09.006
  43. Deepankshi Sharma, Amteshwar Singh Jaggi, Kiran Arora, Anjana Bali. Exploring the role of cAMP in gabapentin- mediated pain attenuating effects in chronic constriction injury model in rats. Braz. J. Pharm. Sci. 2022;58
    https://doi.org/10.1590/s2175-97902022e19362
  44. Amanda Brain, Mark Banting. Nefopam for pain control in Duchenne muscular dystrophy. BMJ Support Palliat Care 2023;13:e778
    https://doi.org/10.1136/spcare-2023-004373
  45. Hyo-Seok Na, Ah-Young Oh, Bon-Wook Koo, Dae-Jin Lim, Jung-Hee Ryu, Ji-Won Han. Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery. 2016;95:e3705
    https://doi.org/10.1097/MD.0000000000003705
  46. S. Sukhbir, S. Yashpal, A. Sandeep. Development and statistical optimization of nefopam hydrochloride loaded nanospheres for neuropathic pain using Box–Behnken design. Saudi Pharmaceutical Journal 2016;24:588
    https://doi.org/10.1016/j.jsps.2015.03.020
  47. Sung Mi Hwang. For the peace of postanesthesia care unit. Korean J Anesthesiol 2018;71:173
    https://doi.org/10.4097/kja.d.18.00113
  48. Andrii Semenenko. Nefopam hydrochloride as a component of multimodal analgesia in the postoperative period. PMJUA 2020;5:68
    https://doi.org/10.31636/pmjua.v5i2.4
  49. Neelam Sharma, Sandeep Arora, Jitender Madan. Nefopam hydrochloride loaded microspheres for post-operative pain management: synthesis, physicochemical characterization and in-vivo evaluation. Artificial Cells, Nanomedicine, and Biotechnology 2018;46:138
    https://doi.org/10.1080/21691401.2017.1301459
  50. Young Seok Jee, Hwang-Ju You, Tae-Yun Sung, Choon-Kyu Cho. Effects of nefopam on emergence agitation after general anesthesia for nasal surgery. 2017;96:e8843
    https://doi.org/10.1097/MD.0000000000008843
  51. Qiuru Wang, Jian Hu, Shuwei Ye, Jing Yang, Pengde Kang. Efficacy of Oral Nefopam on Multimodal Analgesia in Total Knee Arthroplasty: A Prospective, Double-Blind, Placebo-Controlled, Randomized Trial. The Journal of Arthroplasty 2024;39:2061
    https://doi.org/10.1016/j.arth.2024.02.059
  52. Yehun JIN, Seung-Kwon MYUNG, Hangil KANG, Woosik EOM, Daehyun KIM. Effects of Intravenous Nefopam on Pain Relief in Patients with Acute Postoperative Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Korean J Health Promot 2024;24:56
    https://doi.org/10.15384/kjhp.2024.00052
  53. Jetlir Trungu, Fatima Laarbaui, Mélanie Dechamps, Philippe Hantson. Rapidly fatal neurological and cardiocirculatory failure in a patient recently treated with nefopam. Minerva Anestesiol 2019;85
    https://doi.org/10.23736/S0375-9393.18.13395-5
  54. Mohamad K. Moussa, Nicolas Lefevre, Eugenie Valentin, Alain Meyer, Olivier Grimaud, Yoan Bohu, Antoinne Gerometta, Frederic Khiami, Alexandre Hardy. Dynamic intermittent compression cryotherapy with intravenous nefopam results in faster pain recovery than static compression cryotherapy with oral nefopam: post‐anterior cruciate ligament reconstruction. J. exp. orthop. 2023;10
    https://doi.org/10.1186/s40634-023-00639-3
  55. Eun Jung Chang, Eun Ji Choi, Kyung Hoon Kim. Tapentadol: Can It Kill Two Birds with One Stone without Breaking Windows?. Korean J Pain 2016;29:153
    https://doi.org/10.3344/kjp.2016.29.3.153
  56. Jung-Woo Shim, Dongho Shin, Sung-Hoo Hong, Jaesik Park, Sang Hyun Hong. Efficacy of Multimodal Analgesia with Transversus Abdominis Plane Block in Comparison with Intrathecal Morphine and Intravenous Patient-Controlled Analgesia after Robot-Assisted Laparoscopic Partial Nephrectomy. JCM 2024;13:4014
    https://doi.org/10.3390/jcm13144014
  57. Keum Young So, Hyun Mae Moon, Sang Hun Kim. Nefopam does not influence onset and recovery profiles of rocuronium-induced neuromuscular block: a prospective, double-blinded, randomized, controlled study. Anesth Pain Med 2018;13:286
    https://doi.org/10.17085/apm.2018.13.3.286
  58. Koravee Pasutharnchat, Wichita Wichachai, Rungrawan Buachai. Analgesic efficacy of nefopam for cancer pain: a randomized controlled study. F1000Res 2020;9:378
    https://doi.org/10.12688/f1000research.23455.1
  59. Philippe Girard, Marcel Chauvin, Marc Verleye. Nefopam analgesia and its role in multimodal analgesia: A review of preclinical and clinical studies. Clin Exp Pharma Physio 2016;43:3
    https://doi.org/10.1111/1440-1681.12506
  60. Jeong Il Choi. Use of Nefopam in Perioperative Pain Management; Keeping Nefopam in between. Korean J Pain 2016;29:71
    https://doi.org/10.3344/kjp.2016.29.2.71
  61. Sang Kyu Choi, Cheol Keun Kim, Dong In Jo, Myung Chul Lee, Jee Nam Kim, Hyun Gon Choi, Dong Hyeok Shin, Soon Heum Kim. Adverse Hemodynamic Effects of Nefopam in Patients Undergoing Plastic and Aesthetic Surgery: A Single-Center Retrospective Study. Arch Aesthetic Plast Surg 2018;24:26
    https://doi.org/10.14730/aaps.2018.24.1.26
  62. Hyean Yeo, Ji Won Choi, Seungwon Lee, Woo Seog Sim, Soo Jung Park, Heejoon Jeong, Mikyung Yang, Hyun Joo Ahn, Jie Ae Kim, Eun Ji Lee. The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial. JCM 2022;11:4849
    https://doi.org/10.3390/jcm11164849
  63. Jade I Basem, Tiffany Lin, Neel D Mehta. A Comprehensive Review: Chronic Pain Sequelae in the Presence of Ehlers–Danlos Syndrome. Curr Pain Headache Rep 2022;26:871
    https://doi.org/10.1007/s11916-022-01093-z
  64. Dong Hee Kang, Su Young Kim, Hyuck Goo Kim, Jung Hyun Park, Tae Kyun Kim, Kyung Hoon Kim. Earlier treatment improves the chances of complete relief from postherpetic neuralgia. Korean J Pain 2017;30:214
    https://doi.org/10.3344/kjp.2017.30.3.214
  65. Emmanuelle Loyrion, Gilles Francony, Dan Benhamou, Pierre Albaladejo. Inadvertent intrathecal injection of nefopam during spinal anaesthesia. 2017;34:322
    https://doi.org/10.1097/EJA.0000000000000596
  66. Jie Ning, Jing Luo, Zengdong Meng, Chong Luo, Gang Wan, Jie Liu, Sanrong Wang, Xingye Lian, ND Melgiri, Yang Sun, Rongzhong Huang. The efficacy and safety of first-line therapies for preventing chronic post-surgical pain: a network meta-analysis. Oncotarget 2018;9:32081
    https://doi.org/10.18632/oncotarget.22611
  67. Yaqun Li, Woong Mo Kim, Yu Jun Lee, Dong Ho Kang, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon. Antinociceptive effects of nefopam activating descending serotonergic modulation via 5‐HT2 receptors in the nucleus raphe magnus. European Journal of Pain 2024;28:252
    https://doi.org/10.1002/ejp.2173
  68. Sarbjit Singh, Gajulapati Veeraswamy, Deepak Bhattarai, Ja‐Il Goo, Kyeong Lee, Yongseok Choi. Recent Advances in the Development of Pharmacologically Active Compounds that Contain a Benzoxazole Scaffold. Asian J Org Chem 2015;4:1338
    https://doi.org/10.1002/ajoc.201500235
  69. Matthieu Delaye, Arthur Geraud, Julia Delahousse, Angelo Paci, Daphné Morel, Sophie Broutin, Sophie Laurent, Paul Gougis, David Combarel, Celia Lloret-Linares, Florian Scotté. Management of Pain Medication in Patients With a History of Bariatric Surgery: A Systematic Review. Journal of Pain and Symptom Management 2024;67:e859
    https://doi.org/10.1016/j.jpainsymman.2024.01.025
  70. Yong-sook Park, Young-baeg Kim, Jeong-min Kim. Status Epilepticus Caused by Nefopam. J Korean Neurosurg Soc 2014;56:448
    https://doi.org/10.3340/jkns.2014.56.5.448