Korean J Pain 2016; 29(2): 86-95
Published online May 1, 2016 https://doi.org/10.3344/kjp.2016.29.2.86
Copyright © The Korean Pain Society.
Michael W. Carter, Kathia M. Johnson, Jun Yeon Lee*, Claire E. Hulsebosch, and Young Seob Gwak**
Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, TX, USA.
*Department of Physiology, Daegu Haany University, Daegu, Korea.
Correspondence to: Young Seob Gwak. Department of Physiology, Daegu Haany University, 136 Shincheondong-ro, Suseong-gu, Daegu 42158, Korea. Tel: +82-53-770-2288, Fax: +82-53-770-2254, email@example.com
Received: January 6, 2016; Revised: February 12, 2016; Accepted: March 5, 2016
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The present study was designed to examine the functional recovery following spinal cord injury (SCI) by adjusting the parameters of impact force and dwell-time using the Infinite Horizon (IH) impactor device.
Sprague-Dawley rats (225–240 g) were divided into eight injury groups based on force of injury (Kdyn) and dwell time (seconds), indicated as
After T10 SCI, higher injury force produced greater spinal cord displacement (
The present study demonstrates SCI parameters optimize development of mechanical allodynia and other pathological outcomes.
Keywords: Blood brain barrier, Bladder function, Locomotion, Neuropathic pain, Spinal cord injury, Parameters, Rats