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Fig. 5. The expression of inducible nitric oxide synthase (iNOS) at the ipsilateral dorsal horn of L5 spinal cord across time. The levels of iNOS were significantly increased in the vehicle-treated group and the experimental group (group E) compared with the sham-operation group (P < 0.05). The expression of iNOS was markedly decreased in group E compared with the vehicle-treated group throughout the experimental period (P < 0.01). The sham-operation group, sham group; the vehicle-treated group, the control group treated with intraperitoneal normal saline daily after 3rd day following spinal nerve ligation (SNL) until the end of the study period; Group E treated with intraperitoneal 20 mg/kg of gabexate mesilate daily after 3rd day following SNL until the end of the study period.
The Korean Journal of Pain 2020;33:30~39
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