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Fig. 4. The levels of interleukin (IL)-1 (A), IL-6 (B), and tumor necrosis factor-alpha (TNF-α; C) at the ipsilateral dorsal horn of L5 spinal cord across time. The levels IL-1, IL-6, and TNF-α were measured at the 7th and the 14th day following spinal nerve ligation (SNL). The expressions of IL-1, IL-6, and TNF-α were significantly increased in the vehicle-treated group and the gabexate group compared with the sham-operation group at both 7th and 14th day after SNL (P < 0.05). After administration of gabexate mesilate, the expressions of IL-1, IL-6, and TNF-α were significantly attenuated in the gabexate group compared with the vehicle-treated group at 7th day after SNL (P < 0.05). However, there were no statistically significances in the expressions of IL-1, IL-6, and TNF-α between the vehicle-treated group and the gabexate group at 14th day (P > 0.05). The sham-operation group, sham group; the vehicle-treated group, the control group treated with intraperitoneal normal saline daily after 3rd day following SNL until the end of the study period; Group E, the experimental group treated with intraperitoneal 20 mg/kg of gabexate mesilate daily after 3rd day following SNL until the end of the study period.
The Korean Journal of Pain 2020;33:30~39 https://doi.org/10.3344/kjp.2020.33.1.30
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