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Fig. 3. The expression of p65 subunit of nuclear factor-κB at the ipsilateral dorsal horn of L5 spinal cord across time. The levels of p65 were significantly increased in the vehicle-treated group and gabexate group compared with the sham-operation group (P < 0.001). The expression of p65 was markedly decreased in the gabexate group compared with the vehicle-treated group (P < 0.05) throughout the experimental period. The sham-operation group, sham operation only without spinal nerve ligation (SNL) or drug; the vehicle-treated group, the control group treated with intraperitoneal normal saline daily after 3rd day following SNL until the end of the study period; the gabexate group, the experimental group treated with intraperitoneal 20 mg/kg of gabexate mesilate daily after 3rd day following SNL until the end of the study period.
The Korean Journal of Pain 2020;33:30~39 https://doi.org/10.3344/kjp.2020.33.1.30
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