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Fig. 1. Bromelain reversed thermal hyperalgesia in sciatic nerve-induced neuropathic pain. (A) Presurgical hotplate test. (B) Third day post-surgery hotplate test. (C) Seventh day post-surgery hotplate test. (D) Fourteenth day post-surgery hotplate test. (E) Twenty first day post-surgery hotplate test. Each value represents the mean ± standard error of the mean of each group. PWL: paw withdrawal latency. aP < 0.05, aaP < 0.01, aaaP < 0.001 compared with unligated control (normal control); bbP < 0.01, bbbP < 0.001 compared with ligated control; and cP < 0.05, ccP < 0.01, cccP < 0.001 compared with gabapentin (reference control).
The Korean Journal of Pain 2020;33:13~22 https://doi.org/10.3344/kjp.2020.33.1.13
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